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1:00:17that param mutation is probably happening in mammals. I mean it's happening in plants so ubiquitously. It should pro there there shouldn't be there's no like um first principles reason why it shouldn't be happening in mammals, right? But you need to you need to actually get get the evidence. And for for a long time the it was largely at the level of theory. Now why is that the case? Why is it so hard to prove? So it has to do with measuring DNA methylation. >> Okay. >> Okay. How does one if I get a strand of DNA? It's actually very easy to sequence DNA. Okay. There's ever since the days of the 1960s and 70s. I mean we've sequenced the entire human genome. Now
1:00:58we've se sequenced tens of thousands of human genomes. I think it's up to the even might be millions now. So, you know, sequencing DNA is not a big deal because it's distinct A T GC, right? There's ways that I can make the A like combine with um a T that has a little fl like, you know, a little GFP tag that like lights up a certain color. So then like every time it's red, I know it's an A. Every time it's a G, I know it's it's green, it's a G, right? And like there's so many cool sequencing technologies, but those sequencing technologies aren't good with methylation. Okay, one way to do it that a lot of people use is
1:01:39bulfide sequencing. Okay, here's how you do it. You take your you take your DNA.