The Nature Genetics mouse paper

1:13:28that we were talking about. Okay. Non-Mandelian inheritance of DNA methylation patterns in mice. It was out in Nature Genetics. It was during my paternity break and I was like, "Oh, this is really cool." >> But now I can read that title and understand why this is a big deal. >> That's right. And you miss me. >> Yeah. Like this is [laughter] ladies and gentlemen, the greatest. This is why it's the greatest. But like and it's it's important because these words have meaning. A lot of times people see these titles and they're just like, "Ah, >> it's just big words. They don't mean anything." There's actually real Even in the short title. >> Even in the short title, you get it. And it's in mice, not transgenic mice, not like special mice, just mice, just plain old mice. That's why it's very important. You're doing it in mammals,

1:14:08right? >> Because this is from the 2006 one. This is basically the next stage, the next development there. >> Yeah. The um one of the key authors, Andrew Fineberg, he's from Johns Hopkins. Okay. He has a career in disease genetics and epigenomics. He's like one of the epigenomics guys at the conferences, right? Like that's like giving the presidential lecture or whatever. Um and then David um Threadgill at Texas A&M, he's been studying humanlike complex genetics in mice. So they decided that they wanted to collaborate about 10 years ago um trying to study epigenomics in the mouse model and they're trying to compare methylation patterns in response to diet in these inbredad strains. And they realized that in order to do that they

1:14:49what they really want to observe is alals specific epigenomics. Meaning this alil came from the mom, this al came from the dad. How is the methylation changing? All of that kind of stuff, >> which this methodology we just talked about before is an enabling layer to that specific research question. >> Exactly. Yeah. And so now we can we can start doing that. The model that they