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1:23:24What we're looking at here is effectively paramutation. >> Okay. Okay. >> So in this one, in this particular region, >> the mom has let's say intermediate methylation. The solid pink line is like 50%. >> The dad is all the way down to like 10%. Okay, those are the solid green line that's way down there in that highlighted region. and the mom is down. There's a dip, but it's only 50%. The dotted pink line and the dotted green line are all on top of the green. None of the mom's effects of methylation have come through in the in the
1:24:05subsequent offspring. Okay, so that's that top part. >> Now, let's look at the F2 generation, okay? Which is in the bottom. Every single offspring has the methylation pattern of the dad. >> It's like the mom's methylate. Like obviously the genes are there, >> right? But the mom's methylation pattern is completely gone. The mom's epigenetics have been completely silenced >> in both F1 and F2. >> Yes. And and and in F2 subsequently. Yes. >> Yeah. >> F2 is there to show that like whatever happened to F1, it didn't recover. >> Right. >> Right. What whatever happened in that first generation, the grandkids now just get no influence from the mom's epigenetics. All of the epigenetic influence is coming from the dad. >> That's in this particular.
1:24:46>> Right. Right. Right. Right. >> Right. Right. This is very weird. >> This is very weird because what >> this is something that we saw in the maze, right? Where it's like it's like even when when I crossed the the purple with the green, >> it was only green. >> Even the grandkids all were all green. >> This was the suppression thing we talked about there. >> This is and now the the the alil is completely suppressed. >> And so we're now we're seeing this in animals as well. We had seen it in the the maze before, but now we're seeing it in more complex Yeah. >> biology, which is >> fascinating. And there there's some very cool like consequences of this that we'll talk about at the very end. Okay. Um the last few figures that I want to talk about um this next one, figure
1:25:27number 34, this is I think figure six