Ultra-long reads and methylated cytosines

1:09:31>> Why is this advantageous? One, you can do ultra long reads. You're not treating the thing with detergent, >> right? You just you just you just you just stick this thing through and you can get hundreds of thousands of base pairs. We're going from 150 to now several orders of magnitude of like how long you can make the read, right? So, it's like the it's like, you know, when when sometimes you you you like go to the Airbnb and like you open the puzzle box and half of it's done. >> They're like, "Do [laughter] >> Right." cuz then because then you can post it on Instagram like two hours later I did it [laughter] >> that that's it's a really interesting note though that through this biohysical detection method which again was used

1:10:11for sequencing the point is because we understood the methylation process in and of itself you could then extrapolate that the C in this biohysical detection is going to just have again that slightly different fingerprint and that's all Yeah, that's all you need to look for now. And and again, just this narrow now we can and again now being able to sequence longer. >> Yeah, it's huge. >> Gets back to this uh chromatid. >> Uh >> yeah, because now you've got a longer sequence. There's in a 100,000 base pairs, you're going to be able to identify which one came from the mom and which one came from the dad. >> 100%. >> Wow. >> Isn't that sick? >> And and and the thing is this Oxford nanopore evolution was not necessarily

1:10:53for u methylation uh detection. It's just someone was like, "Wait a minute. Yeah, this is the the physics works out here, right? Um, it's called Oxford Nanopore detection because it was a technology licensed by Oxford Nanopore Technologies of Oxford, UK. They licensed the patent, but the patent actually is a University of California patent.