Organ- and sex-specific methylation

1:27:42all of this stuff is really really cool, but here what we're seeing is a difference in one organ dependent methylation. So the same region in the liver versus the muscle. The muscle has about 80% methylation in both males and females and in the liver the males have 80% methylation but the females have something like 50% methylation. >> This is crazy. >> Highly significant. >> This is crazy. Okay. >> So you can also have divergence across >> organs on top >> and on top of sex. Now why is this important? This was found so it's hyperthylated in females and then not that much in males, right? Why is this

1:28:23important? Well, it's found exclusively in the liver. What does the liver do? One of the big things that the liver does is um dictate tissue specific like it dictates um hormonal environments. It dictates how drugs are detoxified. So, this could be one of the main reasons why certain drugs work one way in one sex >> and then not >> in another sex. >> Yeah. >> Right. >> Right. >> Cuz that's a known effect. >> Right. We know that. >> That's kind of mysterious. >> This could be it. >> Like the epigenetics is different in the liver but not in other other places. That's a really important potential insight among many in this is that

1:29:05>> there is this organ specific epigenetic difference in methylation in the liver which would affect drug delivery >> um >> or a drug like like efficacy >> efficacy right right >> kind of crazy >> I yeah oh my I'm thinking about so many things but I I want to be not we we will