EP 44 · 1:25:28

Emergent epigenetic patterns

From New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

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1:25:30and seven. This shows um some emerging epigenetic patterns. Again, the main thing to see is that the dotted pink and green lines are different from the solid ones. The one on the left, figure six, that shows something very weird, which is that the offspring sometimes just have more methylation than either of the parents. So that I don't even know how that got there. >> You and Neither of your parents had this. It's not even a blend or one of the parent is dominant over the other, >> which would it make almost more sense. >> Yeah. Yeah. This this one's just like >> this doesn't >> Yeah. That's why they're calling it emergent epigenetic, you know? It's just like >> put it in that bin. >> Yeah. We we'll come back to that later. >> Yeah. Yeah. It's like it's like this

1:26:10happens um and we report it. So now you got a size [laughter] >> and then and then on the right hand side we've got genomic imprinting. This is um again this is similar to the mom and dad thing but here so in the in the mom and dad one um it didn't actually matter which um chromosome which if the if the alil came from the mom or if the alil came from the dad because both sets of alals if they were from the mom or the dad it was alil specific. Here it's actually mom and dad specific. It's a process where certain genes are expressed in a parent of origin specific manner. In this case, the epigenetics is

1:26:51expressed in a parent of origin matter. Okay. So, if the methylation is with the mom, only then is there going to be methylation in the kid. >> Mhm. >> Okay. >> Doesn't matter what type of alil it is, >> which is actually an important distinction. >> Yeah. >> Um Oh, this. >> So, it's a parent of origin. So there's can both be alil specific divergence in methylation uh in you know the F fn generations. Uh and that can be true on top of the fact that there's like this genomic imprinting like they're not necessarily independently true. >> Yeah. So it's super super

1:27:33complex. >> Yeah. Because the the combinatorics >> becomes the com Yeah. Exactly. >> Becomes quite difficult. >> The last one I thought was actually really really cool. Um, I mean I I think

From the episode
  1. EP 44

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

    A new mouse genetics paper suggests that non-Mendelian epigenetic inheritance may be more common in mammals than previously thought.

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

BiologyDNAEpigeneticsGeneticsInheritance