EP 44 · 27:08

Thomas Hunt Morgan and fruit flies

From New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

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27:09it because it's it's coincidence. Okay. you could be missing something that also goes half and half. >> Just because it has similar behavior >> Yeah. >> does not mean it's it's not a causal link. >> Yeah. It's not a causal link. There's there's a there's a correlation, but in order to establish causation, you got to dig deeper, right? And this is where a guy Thomas Hunt Morgan comes in. also at Columbia University early 1900s Columbia was doing amazing with um just like early biology like even before DNA before you know molecular biology just like this kind of this kind of early rudimentary work so Thomas Hunt Morgan at Columbia University he starts using the Drosophila

27:50fruitfly he's the one who actually establishes the fruitfly as the model organism nowadays the fruitfly is used in neuroscience research development genetics all sorts of things he's the first guy to be like, let's do let's let's go to town with the fruitfly. >> So So Mandel was the pea plant and then Morgan now moved us into a more complex biological organism that is a better model organism. >> Yeah, that's an animal so it can like learn and stuff like like it sleeps so you can do like there's so many more things you can do with a drosophila, right? And Morgan's team discovers that there's some traits that are sex linked like red eye color. Here's what I mean by that. So,

28:30um, what he does is he finds, um, a female with red eyes and then a male with white eyes. And when they have offspring, all of the kids have red eyes. So, you could just be like, "Oh, red eye is like this like uh, you know, um, homozygous type dominant trait or whatever. Now, let's take the female again that has red eyes. So, in this case, you're going to this is going to be a hetererozygous female, right? because the male had a white eye. So, this female is going to have um one redeye al and one white al. And now I'm going to cross that with a redeyed male. Okay. >> Mhm.

29:10>> So, the male and and we we've done a true breeding with the male to make sure that the the male is fully red. When we cross it, most of the offspring,

From the episode
  1. EP 44

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

    A new mouse genetics paper suggests that non-Mendelian epigenetic inheritance may be more common in mammals than previously thought.

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

BiologyDNAEpigeneticsGeneticsInheritance