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1:29:28talk for the next three hours. >> I mean, obviously, this has very deep implications. >> That's that's the main headline. >> And um what what it's really saying is look, >> future clinical genetics is now going to need to focus on genetics and epigenetic risk. Okay? If we want to start charting, you know, like how an individual's genome is going to affect their life and so on and so forth, right? There's also some very cool just like fundamental science things that are happening here. um that have to do with like for example evolution right the foundational science of evolution there used to be this theory called the Wington's theory of genetic assimilation basically it's saying that
1:30:08environmentally induced traits can become hardcoded into the DNA right this is not very Darwinian Darwinian is just um natural um natural selection survival of the fittest it's like the offspring get a random assortment and then they live their lives and then if they survive they procreate. Right? What Wington's theory is saying it's it's more Lamarian in the sense that your life is going to dictate the genetic your genetic makeup. Now for a long time this was discredited and for good reason because genetics is like as I said the DNA part is like very hardcoded right but now there's a link between the software
1:30:49and perhaps the hardware. >> Yeah. because methylated cytoines which are um the C's with the methyl groups those are inherently chemically unstable. >> Okay. So what that means is they frequently mutate into thymine T's. So if I have more methylation I'm going to have more mutations and I'm going to have more T's where there should be C's at at three times a higher rate. So what's the conclusion? That means that if among the inherited epigenetic traits, right, if my life is changing the methylation pattern, that methylation pattern could change the
1:31:30hardware itself because of this 3x difference in mutation rate. >> Yeah, it's it's a it's a recursive self-improvement or not improve >> or not improve. Yeah, it could go either way. >> It could go either way. >> Kind of crazy. >> It that's that's a really, you know, it's always been the conversation about