EP 44 · 51:33

DNA methylation explained

From New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

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51:34to doing this that are by and large these are the two level levels of epigenetics. The first one is something called methylation effectively as I told you DNA is made up of four distinct nucleotides ATG and C. Now the C the cytosine can sometimes be modified by attaching a methyl group. A methyl group is I think just CH3. You just take a CH3 part of a molecule and you attach it to the to the cytosine. When you do that, if you've got a bunch of cytosine in a segment of DNA that has these methyl groups, the RNA polymerase can't really get to it because you've altered the the look and

52:15the RNA polymerase comes in and it's like, I don't know what I'm looking at. I'm going to go somewhere else. >> I'm I'm going to go somewhere else. >> Right? So, so this is one way to silence parts of the dean, parts of the genetic sequence by just like adding a little chemical tag. And th those are the little tiny um like red pins that you're seeing. Okay? And they only attach crucially to the C the cytosine. Okay? So the A's, T's, and G's are always left alone. Okay? The the part of what we're

From the episode
  1. EP 44

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

    A new mouse genetics paper suggests that non-Mendelian epigenetic inheritance may be more common in mammals than previously thought.

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

BiologyDNAEpigeneticsGeneticsInheritance