EP 44 · 1:21:47

Non-Mendelian methylation anomalies

From New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

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1:21:48transacting um methylated. What is it? something some something QTLs I I forget what the the full form is what but the me is the methylated part okay >> here what we're looking at >> is let's look at the liver which is the first figure um the the first sort of middle figure okay at the top >> over there what you're seeing is the top line is the pink solid >> the bottom line is the green solid so that's the mom >> methylation and the dad methylation you can see the mom has a lot of methylation in this region the dad has almost no methylation in this which is an invert of what we just >> Yeah. Yeah. But that's not what's important because this this part of the

1:22:28gene might be different. >> What's important is the dotted lines are all in the middle. They're not coinciding to one or the other. >> Meaning that the the I got the DNA from them, >> but then the methyl parts are half and half. >> They're blended. The methylation is blended. That's fascinating. >> That's nonmandelian. That's what we're looking at. Okay. The offspring, some of the methylation is there. Some of the methylation is not. >> That's interesting. Some of the some of the female chromosome is getting more methylated or sorry, no, some of the female chromosome is getting less methylated and some of the male chromosome is getting more methylated. >> Yeah, cuz because based on where they are, they're in they're in >> again the the male is the one that's almost has none, but the the the

1:23:10offspring are blended. And so >> yeah, that's why the dotted lines are all in the middle. >> In the middle significantly higher and the the higher and the opposite of her. Very interesting. Okay. >> Okay. >> Okay. >> Now, let's go to the next one. This one's weird. This is the CAP N11 gene.

From the episode
  1. EP 44

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

    A new mouse genetics paper suggests that non-Mendelian epigenetic inheritance may be more common in mammals than previously thought.

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

BiologyDNAEpigeneticsGeneticsInheritance