EP 44 · 31:29

Linked genes and the first major crack in Mendel

From New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

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31:29happen to be inherited together. Okay. So, you know, before I was I was showing you about how um body color and eye color under Drosophila, they were independently assorted. Yes. But there's some that >> if I have red and some other trait, those are going to go together. Okay. Why would they go together? Well, now it's obvious because if they're on the chromosome, if they're on the same chromosome, then they're coming in a package, right? And so if if if they're coming in a package, you're going to have this correlation and that violates Mendle's law of independent um assortment. >> If I order something from Amazon, >> we thought it was going to come in two separate packages which could have two different delivery dates, but it

32:10actually came in a big box with two little boxes in it and they were shipped at the same time. Yeah. Very bad crude analogy but >> no, but that's exact that's exactly what's happening, right? And this this is actually the first major empirical crack um to Mendele's laws. Okay. This is the first time where it's like no Mendle was actually wrong, but also he did it's fine. Like he had no idea what you know um >> he did it in a cave with a box of scraps. >> Yeah. Exactly. Yeah. Yeah. Yeah. So it's it's fine. Morgan actually won the Nobel Prize in Physiology. He's one of the first um Americans to win the Nobel Prize in Physiology and Medicine. And side note about um Thomas Morgan, he's quite a character. So he's the nephew of Confederate General John Hunt Morgan who who got his butt kicked somewhere in the

32:52north. And then um the greatgrandson of Francis Scott Key who is the um author of the Star Spangled Banner. >> No way. >> Yes. This guy's quite interesting. So he established something called the fly room in Colombia that became kind of this legendary place where scientists from all over the world would come and hang out and learn about how to take care of fruit flies, how to make sure that you know the crossing is the same because for Mendel it's like pretty easy. You just cut the thing, you take a paintbrush. Here you got to like make the flies mate and stuff, right? So it's a bit more of a process but there's a lot more room to to work with

33:32scientifically. It became it became this legendary place um established the

From the episode
  1. EP 44

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

    A new mouse genetics paper suggests that non-Mendelian epigenetic inheritance may be more common in mammals than previously thought.

    New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics)

BiologyDNAEpigeneticsGeneticsInheritance