444 words · auto-generated from the episode video
52:41we're sort of speaking to here is there's in the practice of your body generating the proteins that your genetics sort of has the instructions for. >> That's a whole functional process. >> Yeah. >> In and of itself. And much like all functional processes and it there there are opportunities for it to break down in multiple different places. >> Yeah. And that's where you begin to get the impacts on outcomes because you might have the instructions, but when you go to the factory to build it, the power goes off, the the doors are locked,
53:22>> you you offshore it to China, whatever. >> Yeah. [laughter] Exactly. Yeah. Exactly. Exactly. And so, so that's the first part, the methylation. Okay. The second step is in order to actually create the chromatin, which is the stuff that makes chromosomes. It's like a thicker sort of wool compared to stringy. The DNA is like a string and then the chromatin is like wool. You have to like sort of bunch up a bunch of string together to create the thicker part, right? And in order to do that, what if you if you bring that photo back, you wrap it around these nucleosomes which are made up of histones. Okay? So they're like little proteins that you wrap it around and then those sort of get packaged together. Right? Now if you wrap it
54:02around that part of DNA that's wrapped around the the nucleosome the RNA polymerase can't get to. Right? So this is another level of silencing certain parts of the DNA. If you don't ever want this part of DNA >> to to be expressed in a cell like let's say you're an eye cell. I don't want the proteins that neurons want. package it up and you know put it in a warehouse, put it in your garage effectively, right? Only read the part that tells me how to be an eye. >> And this is where how it's able to control for if all cells all have the same instruction list, how it only focuses on a certain portion, a certain portion of it in order to >> build out the complex different parts of
54:44us where it's not just reading everything and >> not really having >> you don't we don't have like a bunch of mini like Krishna, right? It's like no there's like skin Krishna, hair Krishna and all that all that other kind of stuff. So that is epigenetics. Okay, these two sort of layers that's that's effectively what we want to focus on. Um how do we how does this explain the maze