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1:32:51risk right >> this is a big deal right um because you can explain now how a mutated alil could epigenetically silence a healthy alil >> right so it's not just all about genetics even if you're a hetereroygote and you've got the correct alil to like >> survive the disease >> if you've got some shenanigans going on like this >> and the healthy alil just doesn't even get expressed >> you're biologically null for that gene Right. >> This makes me think about things like um um like anemia being more prominent in like Mediterranean or uh African populations
1:33:32as opposed to and it's like is there >> Well, that one that one is actually a single nucleotide polymorphism. Yeah, that's actually there's like a straight up hardwired genetic difference. That's not an epigenetic thing. Yeah. And that one's well documented because the the the mutation is I believe in the >> that's great >> in the heem protein or something like that that like affects the shape of red blood cells. >> Yeah. Where where you cannot store the um uh hemoglobin as well. Your hemoglobin is uh >> it's like it's like in a weird shape. Some of them are in a weird shape. So then that makes the cell a weird shape. So but there's so many other things, right? And this is like there there are traits I forget which but like there's some traits where like the there's like
1:34:14weak evidence that shows that the grandmother's exposure to stuff >> alters the disease risk of grandchildren. Okay. And maybe that's another episode that we could do. But like this is this is now getting to that question, >> right? And we can now ask we can actually probe at the probe at it um a