Green fluorescent protein can be used to tag proteins so researchers can follow them inside living cells. The discussion explains how a fluorescent marker makes otherwise invisible cellular processes observable under a microscope.
158 words · auto-generated from the episode video
1:38:08>> 1994 application and engineering of GFP. Yeah. So this story starts in 1962 um with Osamu Shimomura at Princeton University. He discovers this protein called GFP, green fluorescent protein in um algae in fluorescent algae. He thinks it's pretty cool. Um, it takes another 30 years for neurobiologist Martin Shali at Colombia and biochemist Robert Roger Cien at UCSD to express that green fluorescent pro protein, isolate the genetics of that green fluorescent protein and then use that in biomedical research to start tagging cellular
1:38:49processes. So now we can watch them live with our microscope. We can use the genetics of the GFP to tag it to a certain protein. So now when the protein moves around in the cell, we can just watch it because it's got this little green tag that's like a little LED light at the microscopic level. >> Little beacon. >> Um they won the 2008 Nobel Prize in chemistry together.