Topic
Neuroscience
Episodes and research papers from From First Principles that help explain Neuroscience from the ground up.
Episodes
Conversations and explainers connected to Neuroscience.
Can AI Help Wake Coma Patients? The Science of Consciousness
A deep dive into how an AI model used real brain data to map coma circuits, predict new mechanisms of unconsciousness, and point to a possible target for restoring wakefulness.
Can Human Neurons Really Play Doom? The Science Behind Wetware
Did a dish of human neurons really learn to play Doom—or is the wetware story more hype than breakthrough?

Roman Concrete, Brain "Cognitive Legos," DeepSeek, and Econophysics
Roman concrete, compositional brains, DeepSeek scaling, and market impact physics.

Hidden Star in Betelgeuse, Dancing Atoms, Ultra-High-Energy Cosmic Rays & VR Immunity
Betelgeuse, quantum atoms, OMG cosmic rays, and deep-space navigation.
Research
Papers and studies featured by the show.
Building compositional tasks with shared neural subspaces
Imagine your brain has a toolkit of LEGO bricks. These bricks represent small groups of brain cells that work together. To build a 'car' (one task), you combine a 'wheel' brick, an 'engine' brick, and a 'chassis' brick. To build an 'airplane' (a different task), you don't need a whole new set of parts. You can reuse the 'engine' brick, but combine it with a 'wing' brick and a 'fuselage' brick. This study found that the brain works similarly, reusing the same neural 'bricks' (called subspaces) in different combinations to handle various tasks, making it incredibly efficient and adaptable.