Rosie’s results and why this matters beyond one dog

6:53down and was a bit sad. And towards the end of January, she was jumping over a fence to chase a rabbit." >> Yeah. So, not only the the the biological decrease by March, but even the behavioral change >> Yes. uh even sooner than that is just unbelievable. >> It's unbelievable, and it's like so incredible, such a cool story. As a former dog owner, um you know, like the the ends of the earth that this guy went to >> Yeah, yeah, yeah. to save his dog, I really identify with that. I thought this was so cool, and it's also the first time that there's a personalized cancer vaccine that's been designed for a dog. >> Yes. Ultimately, this is going to help in humans as well. I'm sure I'm sure the

7:34um New South Wales researchers at the university are like writing a paper right now, cuz this is a great paper. If you're not, you really shouldn't be. Like this is this is something that I can see coming out in a very top journal. Um, and the bigger picture is actually very cool. Moderna and Merck um, the two companies are actually leading the pack when it comes to personalized mRNA vaccines for this purpose. So, in humans, um, where they're going to, you know, again, sequence the DNA from the tumor, and then go back, create the mRNA vaccine. If you can make this cheaper, and if you can iterate on this faster, this is huge for, you know, cancer in human beings as well. I think the next step, um, what

8:15he's going to do is every single tumor on the body is actually different, right? Because every single tumor is a few mutations here and there. So, that's why only 75% of the tumor went away. Because the core of the tumor likely has other mutations that he didn't sequence. So, you can iterate on this. You can apply Now you can get to the smaller inner orbit. Sequence that, and then now get back to the >> the second order, third order, so on and so forth. Um, I just thought this was a very cool, hopeful story in the potential that AI has for just like average people, Yes. >> you know? Like uh, $3,000 sounds like a lot, but I don't know, I would have paid

8:56that for another year or two. Based on the cost of cancer uh, treatments now, I think that's probably bargain basement or close to it. It's It's on the It's not necessarily It's It's not It is It's not cheap, um, but healthcare, as many of us know in the United States, and especially in cases like this, is extraordinarily expensive. >> Yeah. So, anything you can do to chip away at the cost, uh, while still being safe and having efficacy and all the check boxes, is is huge. >> And if you were to compare it to, let's say, like you get a consultant who's a cancer researcher, and you get a whole team to actually do this, it's like pennies compared to like actually hiring a full-fledged team

9:37>> Right. to dedicate to your dog. Yeah. Yeah. >> Yeah. The time and the resources. So, I think I think it's really really cool. And a lot of these the Moderna and the Merck vaccines, they've jointly developed these for melanoma. It's already shown a 49% reduction in the risk of cancer recurrence and death over a 5-year range. So, should be coming out soon. Yes, this is good. >> The only way to have made this a more uh heartfelt lovely story of if if the Sydney dog owner's name was John Wick. Oh yeah. Yeah. Yeah. Yeah. That would That would have just rounded out the story perfectly. Um but great >> But Cunningham is a good enough name.

10:18>> It's >> Paul Cunningham. Paul. >> Props to you, man. >> Yeah. Awes- awesome stuff. Really really awesome stuff. Uh take life into your own hands. Great start with a that sort of interesting angle to an AI story. Our second story is uh a similar gene kind of story, but this one I'm very curious This one's weird. to to to talk to you about. So, the title on this one is gene gene conversion empowers natural selection in fish species. So, there's a tiny Amazon fish that has been uh a fascinating look for researchers for some time. And it get it should not have survived as a species.

10:59>> Yes.