How mRNA trains the immune system

5:08recognize that spike protein, so that when the real thing comes in, we can recognize the spike protein, we can recognize the virus, we don't get full-fledged COVID. We actually have an immune response the first time. It's effectively training the body's defense forces for what the enemy is going to look like before the enemy is on your shore. Exactly. And over here, the enemy is already on our shore. Yes. But the problem is that cancer is very deceptive. Cancer has a lot of mechanisms to suppress the immune response. And then also, the cancer is our own DNA. So, our immune system isn't like as good at targeting cancer versus something that is fully foreign, right? Because when it's fully foreign, and obvious. Right. But with cancer, it's like your own

5:48cells are actually acting up. So, here's what he did. He pinpointed the mutations that were driving the cancer in that tumor, and then he made an mRNA that would train Rosie's immune system to target that specific tumor. Okay? He also actually had to um additionally put in things that would suppress that immune suppression. So, it's like a double negative. >> Yeah, yeah, yeah. Right? Cuz like the cancer is telling the immune system, "I'm don't don't come at me." So, there's a suppression there. He had to put in a bunch of drugs that actually like told the immune system to ramp back up. >> Right. Okay? So, this double double-edged sword kind of went in, and

6:29it's incredible. Less than two two months less than two months after the sequence was finalized, Rosie received her first injection in December, and by March, 75% of that tennis ball-sized tumor was gone. There's a great quote from this article from a Paul Cunningham who said, "At the start of December, her mobility was way down at the beginning. Uh she started to shut