Translational path: TNAP inhibitor SBI-425 mimics effect orally in mice

1:38:12>> Mhm. >> Right now, this is a we're we're taking our understanding from the study. Yes. That it's about boats anchoring to the dock and too many boats anchoring to the dock that is then >> creating the physics of the dock to not be tight and be loose and now there's leakage. Well, what if we just like messed with the boats, >> right? The team, >> right? >> And that's what they did. >> Okay. >> And the oral SBI 425, it successfully mimicked this GLD1 gene therapy. >> Oh, in the mice. >> Wait, wait, wait, wait, wait, wait, wait. This is actually probably the craziest piece of this. So, so in the mice, we had to do gene therapy in order to to instigate.

1:38:54>> We have to do this like weird stuff that we can't do in humans. But now it's like what if we just feed the mice this this drug >> right which is already >> approved >> approved for a different use case. >> Yeah. Yeah. Some some random you know calcification. >> But the point is it has the same it it creates the same exact GL GPLD1. I keep saying GLP1 GLD1 >> uh uh generation enzyme generation. >> Yeah. >> Just take and it's already an oral format. >> Yeah. It's already in oral format and it's mimicking the gene therapy. Right. Maybe it's not doing what the gene therapy exactly is doing, but effectively what do we want? We want to maintain the bloodb brain barrier. That

1:39:35is our end case. >> Yes. >> Right. Yes. >> And by whatever means necessary. Well, we already have >> SBI 425 that's been approved for other stuff. >> Yes. >> And it's doing it >> right. Right. >> So now this is now a bioavailable pill. >> Yes. >> That can treat Alzheimer's. >> Yes. purely by targeting the bloodb brain barrier, by targeting this vascular interface between the blood and the brain. Maintaining that, >> it circumnavigates this historic bloodb brain barrier drug delivery problem. We don't have to worry about does is it going to get through? Because what we're worried about is actually maintaining it in the first place. >> Yes. We want to make sure that in the analogy we brought up about TSA in the airport um or the boat and the dock in

1:40:16the Coast Guard, uh we want to make sure that the Coast Guard is always patrolling the dock. >> Exactly. Because what's happening is Coast Guard over time people retire and then there's not enough we staffing issues >> and and then all of a sudden these teen apps are just having a field day kind of like the Chinese fisherman people off the coast of Chile and all over the place that are just totally >> exactly >> unregulated. But if you had some Coast Guard there and then there's no less TAP and then >> and the final thing I want to bring up about this paper is they did do their homework with actual human tissue cuz so far it's always in been in um >> in mice in in particular mice.