2020 discovery: GPLD1 from liver improves cognition but can’t cross BBB

1:25:02>> this is Can we just hold on this for a quick second because I think this is important. So what you're saying is in this in this 2020 paper >> Mhm. >> in science >> we had this understanding that when you exercise all your body starts sending these extraines and >> they're sort of like bene like the benefit of that is it it helps sort of sustain uh it's like a almost like this maintenance process. Yeah. for the body where it keep it keeps you at stable state for lack of a better way to put it. >> We we know that it comes from exercise which drives a process that the body enacts >> the discovery that there is a singular protein that comes out of the liver.

1:25:43>> Yeah. >> In this in this 2020 paper >> that is improving cognition >> is is improving cognition out of all the extra kinds. >> Yeah. And other ones could be as well, right? But this one particularly found this that is like the signal is way high. of all the impacts, this one is the one that has the most and is a is a key for uh focus and attention. I just I just think that's a kind of a crazy idea in and of itself. >> Yeah. There's there's an enzyme coming out of the liver. >> Yeah. >> There is an enzyme coming out of the liver that is improving cognition demonstrably right >> in older mice when they do exercise. >> Right. >> Right. >> That's fascinating. Okay. Okay. >> Yeah. And that was in 2020. There's a

1:26:23problem though. >> Okay. This enzyme GPLD1 is massive. >> Okay. >> So, it's not making it through the bloodb brain barrier. >> Uhhuh. Okay. >> So, what exactly is it doing? And that's why there's a giant, you see the question mark, BBB, and then there's a question mark and it points to the hippocampus. Like, yeah. What is going on? How is this massive GLD1 enzyme >> that cannot cross the bloodb brain barrier? I mean, even glucose can't pass the bloodb brain barrier, let alone an enzyme of this size. So, how exactly is it making my smarter and their and their brains bigger? >> Because it's not going directly to the source apparently because it can't pass >> because it can't it can't. So, what is it exactly doing? And that is what this 2026 breakthrough is about. Okay. It's

1:27:05unpacking the mechanistic reason how that GLLD1 is affecting the brain. Okay. It's not actually going through the bloodb brain barrier. It's maintaining the bloodb brain barrier itself. >> Ahu. >> Okay. >> Okay. It's like it's like the gates