Cognitive tests improve with GPLD1 treatment (maze/recognition)

1:34:00introduce GPLD1 >> into these aged mice who already have an accumulation of tenap happening. >> Yeah. >> And it still works when it's not necessarily coming from exercise >> because it's the same enzyme. >> Yeah. >> So it doesn't necessarily it doesn't have to come from exercise. >> Yeah. It's like this this singular benefit from exercise we can replicate by just injecting. >> Right. and then we're good to go. >> And we're seeing that even when the you don't have to do it preemptively or preventatively. No, >> you can do it even. >> This is already an old mice that has Alzheimer's like symptoms. It's bad at the Y maze, >> right? And you you artificially insert it and it's got it gets better. >> It gets better. It finds the cheese,

1:34:41>> right? So, this is huge. And for blood um blood brain barrier repair, right? So, let's look at the difference between how much leakage is happening >> when you've got an aged mice >> that has leakage versus one where we treat it with GPLD1. On the left, you can see the the pink is all of where the leakage happened. Okay? It's all over the hippocampus. This is a slice of the hippocampus. On the right, most of the pink is on that bloodb brain barrier in the corner. there's no huge spots in the middle of the neurons because there's not that much leakage because you've treated them with GLD1, right? So,

1:35:22>> I think this is this is really really cool. >> This is this I mean so it's cool for a couple of reasons. It's again understanding, you know, it's like think what you talked about like connecting the biochemistry processes of the body >> to these neurological like long-term >> symptoms >> symptoms >> and being able to trace that story