Parabiosis → “young blood” → exercise signals (exerkines)

1:23:00>> Mhm. >> Like that's the first kick. >> Yeah. That's the first and that we know that's true. >> That Yeah. You did the surgery, you make them share blood. Boom. >> It's done. Yeah. >> And so when we look at an activity like exercise, so the point is it's indicating that oh like the blood has an impact >> on neurological >> Yeah. >> maintenance >> and growth and degradation. >> Exactly. Yeah. >> And exercise impacts the blood. >> Yeah. >> The more you exercise, the more it keeps it sort of let's say youngish. >> Exactly. And actually the exercise impacts the blood in a very specific way because there's signaling molecules that are released by our organs during

1:23:41exercise. They're called exorces meaning like these signaling molecules. Exer meaning it's coming from exercise. And examples are like Iin which stimulates brain derived neurotropic factors. Neurons live longer that way. There's more synaptic plasticity. There's clusterin which reduces neuroinflammation. So all of our organs are releasing this. The muscles release stuff. The heart releases stuff, the kidneys, the liver releases stuff, even the bone releases stuff into our blood. >> And these are all signaling fl factors that facilitate like interorgan communication like if the brain wants to coordinate with the liver, the liver wants to coordinate with the kidneys and so on and so forth. And all of this is happening in our blood. And so the key >> insight here is that well

1:24:23>> how do we make the blood younger? It's because of these exores which are >> released during exercise. >> Mh. And what Sam what Saul Va's lab in UCSF did in 2020 is they reported in science that the exercise was actually bec the the effects of exercise were happening because of this liver derived enzyme GPLD1 whose name I'm not going to say >> but that is the that's the subject of this particular paper. In 2020, they discovered this enzyme. Th