BBB leakage decreases with treatment (repair the “plumbing”)

1:35:45uh which again we only talked about one of the exorind which is this GPL there could be more >> there could be more so again if there's a fundamental >> that's interesting thing independent of the specifics of them looking at Alzheimer's direct like as as their initial use. So and then the then how they then um you know ex tried to test this in mice. >> Yeah. and saw the >> they did all the right things, right? And when we compared it to the amoid uh experimentation and why it didn't work, it like it it clearly works or it doesn't.

1:36:26>> You know what I mean? Exactly. Like like you have a myoid plaques in people and they're fine, >> but when you introduce this GLPD1 into it, it it's not like they just continue being ineffective at the Y maze. >> Exactly. Yeah. And and you know, one could say, oh, this is um this is in mice. There's obviously going to be issues right? >> Always. >> Always. >> That's what's cool about this. >> Okay, that's what's cool about this. So, TAP like Okay, so >> how did they implement GLD1 in mice? >> Yes. >> They've got this procedure where what you effectively do is you increase you you put the gene for GLLD1 inside a viral vector or like in some kind of plasmid chunk of DNA. You stick that in

1:37:06a mice. Mhm. >> Um, you increase the blood pressure such that the liver gets infused with this piece of DNA and then the liver makes >> the GLD1. Can't do that in humans. >> Okay. But here's what's cool. >> The TAP >> is already something that we've been worried about. >> Okay. >> Okay. That TAP gene, the boat that gets anchored, that's already something that we've worried about. And there is a small molecule drug called SBI425 >> that is already approved. >> Okay. to inhibit tenap. >> Okay. >> The boat. >> Okay. Yeah. >> It's already getting in the way of the boat. And it's successfully been used in pre-clinical studies to prevent blood

1:37:46vessel calcification because remember TAP has to do with calcification and bone meation. So like sometimes like there's calcification like calcium deposits that happen in blood. And so this particular drug was developed >> in order to circumn that. But it's like, well, this thing doesn't have to cross the blood brain barrier because what it could do is go into the blood and inhibit the boats from anchoring.