The discussion references a 2004 IEEE paper describing early histotripsy experiments, where focused ultrasound was used to bore holes through tissue via cavitation. Doppler imaging was used to show that fluid could pass through the resulting hole, demonstrating the mechanical nature of the effect. The chapter ends on a teaser that lab mates complained the ultrasound setup was too loud, which reportedly pushed further changes to the approach.
90 words · auto-generated from the episode video
9:06That makes sense. That actually makes sense. Very cool. And so, you know, the first paper that you had, I believe this was in 2004, where it's in the IEEE journals, I believe. And I have a few figures from there where you show that you can cause tissue, you can like bore holes in tissue using this cavitation approach. And then you also use like Doppler imaging to show that like fluids can cross this hole and things like that. But there's like some interesting stories that I've heard