Why current vaccines are reactive, not proactive

1:31:33with Bio BioNTech. They They made a They made a They made They made something called the M-001, and what it was doing was trying to target the stalk of that protein, which is highly conserved. Like the the doorknob versus the hole where the key goes in. >> Exactly. Like what if we just like go for the doorknob itself, okay? Recombinant protein, it targeted nine conserved T-cell epitopes. It went really great until phase two. Okay. And then phase three completely failed. 12,000 people, October 2020, showed no significant difference in flu illness. So, we can't just remove the the We can't just remove the door knob with the lock on it because the the little door is still is still

1:32:13>> the the door knob thing isn't working. Isn't working. Okay? Somehow the door knob thing isn't working. >> I've got to take us on this weird analogy path, so feel free to pivot if we need to. >> no no no no no now we're stuck, baby. But, let's go. So, somehow somehow the idea of like this this invariant thing that I want to recognize is no longer working. So, the failed autopsy is the following, right? Which is that this T-cell that's getting activated to recognize the door knob, it's insufficient. Because what it needs to do is it actually needs to prime the innate cells in the respiratory tissues. That seems to be the problem. That was the lesson that we learned. The infantry, not the special ops. The

1:32:54special ops can know, but if the infantry doesn't, it doesn't matter. >> If the infantry don't know, then it's too late by the time that the infection actually progresses. Okay? And that's where we get into the paper that we have here. Out of Stanford, it's by the lab of Bali Pulendran, integrated organ immunity. It's this idea that we need to shift from specific antigen matching to now target this T-cell activation and fundamentally upgrade our system such that we can really think about a holistic approach about how the organ is actually doing this pro- protection, okay? The

1:33:36protection requires continuous synergistic dialogue between your adaptive immune system, which is the special ops, and your structural cells that are in the tissue that are part of your innate immune system. >> I'm so mad that this perfectly maps on to basically saying we need to build the CIA intelligence agency for the the human body body >> communicate intelligence. >> Yes. Uh we can't have sequestered