“One vaccine to rule them all” — why this idea is so radical

1:30:05genetic elements get reshuffled and now you have an entirely novel HA protein on the outside of the virus. This is what actually happened in 1918 with the Spanish flu. You had this driver where a human being had a swapping of elements inside that created this incredibly different virus that no one had ever seen, right? And that's why nobody was immune to it. So, we've been trying to figure out a universal vaccine that just like is it stays invariant across all of this nonsense, okay? >> Right. >> The The first one that I can really think of

1:30:47is one that targeted conserved internal proteins. Here's what I mean by that. The HA, which is this protein that is in in our analogy the lock, so to speak, it's on the very outside of the virus. There's a little stalk that protrudes out that presents this to the outside, such that the virus can actually get into our human cells. >> Like the doorknob. >> Exactly. Yeah, yeah, kind of like that. But it it Okay, let's let's continue with the analogy, right? We've got the lock. The lock is really the hole that the key is in. What if I could make um What if I could make a little thing that recognizes the shape of the lock itself? Like the little round that goes

1:31:28around the doorknob, >> Yeah. right? >> Yeah. That's what the strategy was here