The search for a way to rebuild

4:29>> We don't grow new neurons, right? But it turns out there might be a way to grow some of the scaffolding around neurons that is the problem in MS and a lot of these other disorders. So in this episode, we're going to go over some of the fundamental neuroscience behind what is MS and these adjacent conditions. Um where the current therapies are lacking and then this new paper which uses this emerging field of evolutionary pharmarmacology >> to propose a possible rebuilding therapy. And what I really like about this paper is the method by which they all figured this out. It's a really nice story because it starts from very large, you know, what how does a yak adapt to

5:10the Tibetan plateau and these researchers are honing in on that mechanism and it's like a detective work in some sense because you're you're going through molecular biology, cellular biology to try and understand what is the exact mechanism that the Yak genome has developed to um let these animals survive and not only survive but thrive in this hypoxic environment where there's lot not a lot of oxygen. It turns out that environment is very similar to the kind of stuff that we're getting in MS. And if we can borrow that then we could possibly have a rewind button on MS. So by the end of

5:53the episode you should be able to fully understand this graphic. So whenever you publish in the El Seavier journals which is like neuron cell um they make you do not just a normal graph a normal abstract you know that's every journal has an abstract right you do the abstract and then your main paper >> meaning like a block of sum executive summary in text >> yes in text um the so elvier journals also have a graphical abstract where they've got like a pictorial >> way of showing what exactly is happening and my goal today is to explain that graphical abstract in a lot of detail.

6:34>> Um so by the end you should be able to know every single one of those words, every single one of those arrows. Okay, that's the idea. >> There's a lot of words and a lot of arrows. >> Yes. So before we do that, let's take a brief housekeeping note. >> Yes. For those of you joining for the first time, welcome. We are very excited to have you here on the best science show on the planet. You can follow us across all of our socials at FFP Pod. It's one of the best ways to support our show to get it to more people. A like, a share, a follow, a subscribe helps us in the battle of the algorithm to get people to focus for more than 15 seconds on something that is actually going to

7:16help them learn about the world around them. We've made some huge updates to the website at ffpod.com where you can watch all of our episodes. You can find all of the research papers we cover like this one we just mentioned and get to our interactive apps for the science R&D funding tracker, our new science transfer board where we're looking at the migration of some of the world's top scientists in and out of the country and here in the US. Mostly out >> mostly out of the country. mostly out, but we're still growing the data set. Uh, it's not looking good so far. Uh, and then we also have our America 250 looking back at 250 years of American

7:58innovation and scientific research. These are really great tools to get beyond the episode whether you listen or you watch. And as always, you can find us on all the main platforms, YouTube and Spotify to watch. Apple video is coming soon, but is currently audio only. We really appreciate the support of so many of you who are just as curious and love the minutia and technical detail of science and the way in which an expert and a layman try to work through it together. And with that, we are going to get back into why you all have come to this episode and I'm excited for this because we've been on the quantum side for quite some time. >> Yeah, we've been on the physics and math side for quite some time.

8:38>> That's true. Yeah, cuz we had the the remon and the the Jacobian before that