Gila monsters and GLP-1 drugs

50:02hey, this could be used against diabetes." >> It's pretty crazy. So the the groundbreaking GLP-1 receptor agonist is exanide and it was used to manage type 2 diabetes. The the compound is exanin 4. It was discovered in the toxic saliva of the gilla monster. It's this thing that eats only a few massive meals per year. This thing only eats like a few meals a year, right? So, it needs a way to maintain stable blood sugar. >> Oh my god. Because it's only got a few, you know what I mean? >> It's in this extreme environment where it doesn't have a lot to eat. >> Yeah. Yeah. And so and so humans looked at this and said, "Hey, this could actually be used against type two

50:43diabetes." The success of Xanide and the pathway made scientists go in and engineer osmpic, which is structurally it's like basically a modified form of exanide >> for the human body. >> For the human body. It's like optimized for the human body. But it's it came from the Gillam monster venom. Kind of hilarious. If you're on OMIC, if you're on Wiggoi, or any of the generics, you can thank the Gila monster. >> Yeah. >> Because without that and the research people that spent the time looking at this exotic animal in this extreme environment because the venom >> Yeah. >> you're put you're putting Gila monster

51:23venom derivative in your body. Okay. >> Yeah. That what we're doing. Yeah. >> This is why science matters. It helps you lose weight, right? >> Yeah. This is finally how we're going to get Americans to pay attention. This is why basic research matters. This how we got OPEC the Gilo monster. Everyone's going to be like, "Vote, vote." Now, that's actually so crazy though because Oh, that's so crazy. >> Do you understand how much money Ozmpic is making right now and all of the GLP? The industry is so It's literally a driver of GDP growth. the like CEO of um one of the GP GLP uh um one of the GLP1 creators was like we need to get a

52:04billion people on the planet onto GLPs because it's going to be a driver for America's GDP growth uh when we're struggling to find other areas of G GDP growth. I'm just >> that's that's that's a crazy thing to say. >> I'm just reminding people. >> No, that's a crazy thing to That's literally. And then he's like, "The problem is as we get more people on GLP1s, >> we're we're destroying the GDP growth of like the food industry, right? Because people don't eat as much. So, we have to find is this is this is what this is where we're at. >> Sorry for the digression. >> That was that." Okay, that's actually hilarious. Um, well, Gila Monsters,

52:46Snakes. This particular paper has to do