The Race to the Double Helix — Watson, Crick, Franklin & the Real Story of DNA
EP 19
·9:27

Miescher’s nuclein

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9:27>> Yes. Exactly. >> Which is a fair >> totally fair. >> Totally fair. >> Totally fair. Right. In in the in 1869, actually, there was this guy um Friedrich Misher who identified something called nuclean, which is what we now call DNA. He identified that inside the nucleus of cells there were two different types of compounds. There were proteins and then there was this other thing that he he said was nuclean, but he was like it's probably just like some structural thing. >> He was like you nuclean. >> Yeah. [laughter] Yeah. Because it's in the nucleus. So So I'm going to call it nuclean. And he and it was seen as a monotonous structural scaffold, right? It's it's just like conferring structure

10:08into whatever is really important inside of inside of the nucleus, right? Mhm. >> And um then came uh Feebis Lavine in from 1905 to 1930 he was actually at the Rockefeller Institute which is now called the Rockefeller University. It's on the upper east side of Manhattan. >> Yes. >> Um endowed by the Rockefeller Foundation. >> Yes. [snorts] >> He discovered nucleotides. Okay. So he he was he was going into this nuclean stuff and he discovered that there's these things called nucleotides that really make up >> that that's the structure >> the the structure of nuclean and there's three different parts to a nucleotide. There's some kind of sugar which he

10:51identified as deoxyibbos. It's just a type of sugar. It's like a carbohydrate. He also identified that there's there's a part of the molecule that's the phosphate, >> right? And then if you if if you actually look it up, there's there's another thing called the nitrogenous base. There's something with nitrogen. So there's three different parts to a nucleotide. >> You have a base, you have a sugar, you

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A single-story deep dive on DNA's discovery and its moral baggage.