Rundown 2 — IDEGs / LLM-guided evolution for discovery

29:34right here. >> That thing took me not a reasonable amount of time to build. Uh so, that's our story number one in the rundown. Number two is the cellular cleanup crew. This came out uh January 7th. It's about ID digs, IDGs, which are deleting diseasecausing proteins in nature chemistry. So scientists have found a way to supercharge our cells natural recycling systems to completely destroy cancer shielding enzymes. And we've talked about uh uh T-Rex and and the whole immunity uh immune system and the immune response in our past episodes in season 1. Some really big deep dives

30:16that are great on this. That's what kind of caught my eye on this one. >> Yeah. >> So we have Max Plank Institute involved in this led by George Winter. And the idea here is that most drugs today act as inhibitors that just like block, right? They they they they block the site. They don't really, you know, activate. But >> this this is now recognizing and destroying the targets entirely. >> Yeah. And it's using the body's own machinery. That's I think what's key, >> right? >> It's like it's like it's basically priming these proteins and not not actually like taking care of the problem themselves, but like tagging them for the body's own >> um trash collectors, these E3 liases to

30:59do it themselves. And it's always good to just like have the body do it, >> right? Because you the body has a whole bunch of dynamics. You talk about biology, there's all these variables. >> Yeah. >> There's a lot of variables. >> Yeah. It's if you if you can help the body rather than just do the task yourself, it's always better, >> right? >> So the the analogy was if if a uh standard drugs are like putting a lock on a door to keep a villain inside, IDEGs are calling in a demolition crew to remove the entire room, making sure the threat is gone for good. Yep. >> Again, this is all happening like this like like this is this week. >> This is this week.