Neuroinflammation theory rises

56:49failing at doing its job. >> Oh, this shift that we're we're sort of in the middle of actually right now as more and more papers come out. I think I know where this is going. >> Okay. And um Okay. >> So the the core study that came out in nature um first author Ayata lymphoid gene expression supports neuroproductive microgle function. What they've what they found is a novel immunelike micro gleal state that and they've identified exactly the transcription factor that is required. Mhm. >> They've identified exactly the genes that are involved in this micro gal

57:30state and they've identified how those genes and those transcription factors create the downstream effect of mitigating Alzheimer's. So it's a top down all the way. >> They have a full map. >> They have a full map of of how it's happening and it's it's very very cool. >> Very interesting. >> Okay. So let's start with Alzheimer's, right? It's it's an evolving landscape. Alwa Alzheimer's 1906 described these scenile plaques and neuro fibrilly tangles and the field of neuroderadation has been intellectually sort of focused on these plaques. You can see the really dark plaque in the middle of brain tissue that's going to just get in the way of stuff, right? >> Um then we started targeting