Topic

Molecular Biology

Episodes and research papers from From First Principles that help explain Molecular Biology from the ground up.

Episodes

Conversations and explainers connected to Molecular Biology.

Research

Papers and studies featured by the show.

New Phytologist·

The role of mycorrhizal fungi in the evolution of terrestrial plants: a molecular perspective

Imagine the first plants were like toddlers trying to leave a swimming pool. The dry land was a scary place with no easy way to get food or water. Then, they met fungi, which are like expert miners with a massive underground network of tiny tunnels. The fungi were great at finding water and nutrients but couldn't make their own food. So, they made a deal: the fungi would act as a root extension, bringing the plant water and minerals, and in return, the plant would share the sugar it made from sunlight. This paper uses genetic 'archaeology' to prove this deal happened almost half a billion years ago and was the key that allowed plants to conquer the land, eventually creating the world we live in.

Journal of Experimental Medicine·

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

Imagine you have two types of bacteria - one harmless and one deadly. Scientists found they could take a mysterious substance from the deadly bacteria and use it to transform the harmless bacteria into the deadly type. It was like giving the harmless bacteria a "recipe" that completely changed what they were. The big question was: what was this transforming substance? Most scientists thought it had to be protein (the body's workhorses), but Avery and his team proved it was actually DNA - the molecule we now know carries all genetic instructions for life. Think of it like discovering that the "instruction manual" for life was written in a completely different language than everyone expected.