All Research

Mucosal vaccination in mice provides protection from diverse respiratory threats

Science·
Read the paperDOI: 10.1126/science.aea1260

TL;DR

Imagine a special spray for your nose that teaches your body to fight off all kinds of germs that make you sick, like viruses and bacteria. It's like having a super shield against colds and flus.

Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 ligands with a model antigen, ovalbumin, that provided broad, durable protection in mice for at least 3 months against infection with SARS-CoV-2 and Staphylococcus aureus. In addition, the vaccine protected mice from other viruses (SARS-CoV-2, SARS, SCH014 coronavirus), bacteria (Acinetobacter baumannii), and allergens. Protection was mediated by persistent ovalbumin-specific CD4+ and CD8+ memory T cells that imprinted alveolar macrophages (AMs), enhancing antigen presentation and antiviral immunity. Following infection, vaccinated mice mounted rapid pathogen-specific T cell and antibody responses and formed ectopic lymphoid structures in the lung. These results reveal a class of "universal vaccines" against diverse respiratory threats.

  • 1An intranasal liposomal vaccine combining TLR4 (GLA) and TLR7/8 (3M-052) agonists with ovalbumin (GLA-3M-052-LS + OVA) conferred broad, durable protection in mice for at least 3 months against SARS-CoV-2, SARS-CoV MA15, SCH014 coronavirus, Staphylococcus aureus, and Acinetobacter baumannii, as well as allergic asthma.
  • 2Protection required both CD4+ and CD8+ antigen-specific tissue-resident memory T cells (TRMs), which epigenetically reprogrammed alveolar macrophages to enhance antigen presentation, phagocytosis, and antiviral immunity via RANKL-mediated signaling, independently of IFN-gamma.
  • 3Vaccination induced persistent chromatin remodeling in alveolar macrophages, with sustained accessibility of antigen presentation genes (H2-Aa), interferon-stimulated genes (Ccl5, Ifnar2), and AP-1, STAT, IRF, and NF-kB transcription factor motifs for at least 3 months post-vaccination.
  • 4Following pathogen challenge, vaccinated mice rapidly formed tertiary lymphoid structures (TLS) in the lung within 3 days of infection, enabling accelerated pathogen-specific T and B cell responses and reduced immunopathology including lower proinflammatory cytokine levels.
  • 5The vaccine platform is antigen-agnostic in its protective mechanism: the antigen identity is irrelevant for breadth of protection, as TLR agonists combined with any antigen can engage memory T cells to reprogram resident alveolar macrophages and establish organ-level immunity against diverse respiratory threats.
Science News

M87's black hole flipped its magnetic field

Imagine a bar magnet with a north and south pole. Now imagine that magnet suddenly flipping so north becomes south and vice versa. That's essentially what happened with the magnetic field around the giant black hole at the center of galaxy M87 — except this black hole is 6.5 billion times heavier than our Sun. Scientists noticed this flip by watching the powerful beam of energy, called a jet, that shoots out from the black hole. The direction and behavior of that beam changed in a way that revealed the magnetic field had reversed. It's a big deal because those magnetic fields are thought to act like the engine that powers and steers these cosmic jets, and we've rarely caught one flipping in action.

Scientific American·

The 2026 World Cup's grass is an engineering problem

Imagine you're trying to play soccer in 16 different places across the United States, Canada, and Mexico — some in freezing cold, some blazing hot, some in stadiums with roofs that block sunlight. Half of those stadiums normally use fake grass. Now FIFA, the organization that runs the World Cup, wants every single pitch to feel and play exactly the same way, like a video game where every level has identical physics. To do that, they hired grass scientists — yes, that's a real job — who figured out how to grow special grass on thin mats with plastic underneath so it can be transported like a carpet, stitched with synthetic fibers so it doesn't rip when players sprint and tackle, and tested by literally shooting balls at it with a cannon to make sure it bounces right. Different grass species are used depending on whether a stadium is hot, cool, or dark. It's basically a giant, living, high-tech floor installation that has to survive the world's best athletes running on it.

Nature Genetics·

Non-Mendelian inheritance of DNA methylation patterns in mice

Imagine your DNA is like a huge book of instructions. Mendel's laws are the normal rules for how chapters of that book get passed from parents to children. But there's also a layer of sticky notes on top of the book—called epigenetic marks—that tell cells which chapters to read and which to ignore. This study found that most of the time (about 93%), these sticky notes follow the normal inheritance rules. But about 7% of the time, they do something unexpected: new patterns appear that neither parent had, or a mark from one parent somehow silences the same mark from the other parent (called paramutation), or males and females end up with completely different sticky notes even when they inherit the same DNA. Scientists discovered this by using a new ultra-precise DNA reading technology in mice, and it opens the door to understanding hidden layers of how traits—and possibly diseases—are passed down through generations.

Monthly Notices of the Royal Astronomical Society·

Remarks on the disproof of the unit distance conjecture

Imagine you scatter a bunch of dots on a piece of paper. The question is: how many pairs of those dots can be exactly 1 inch apart? The Erdős unit distance conjecture asked whether there's a specific mathematical formula that limits how often this can happen as you add more and more dots. Think of it like asking how many friendships can exist in a town where friends are defined as people who live exactly one mile apart — there's a suspected maximum, and Erdős guessed what that maximum should be. For decades, no one could prove or disprove his guess. Now, an AI apparently found a specific arrangement of dots (a 'counterexample') that breaks the expected limit, proving Erdős's conjecture was wrong. A team of elite mathematicians then checked and explained the AI's work in this paper.