All Research

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

NatureNature·
Read the paperDOI: 10.1038/171737a0

TL;DR

Imagine DNA as a twisted ladder (the famous "double helix"). The sides of the ladder are made of sugar and phosphate molecules, while the rungs are pairs of chemical letters (A, T, G, C) that always pair up in the same way - A with T, and G with C. This pairing rule is like having a perfect template: if you know one side of the ladder, you can figure out exactly what the other side looks like. This is how cells copy DNA when they divide, ensuring that genetic information gets passed along accurately from cell to cell and parent to child.

WE wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest.

  • 1Proposed the double helix structure for DNA with two intertwined chains
  • 2Identified that DNA bases are paired in a specific manner that suggests a copying mechanism for genetic material
  • 3Demonstrated that the phosphates are on the outside of the structure, contrary to Pauling and Corey's model
  • 4Established that the structure is held together by hydrogen bonding between complementary base pairs
  • 5Provided the foundation for understanding DNA replication and genetic inheritance
Science News

M87's black hole flipped its magnetic field

Imagine a bar magnet with a north and south pole. Now imagine that magnet suddenly flipping so north becomes south and vice versa. That's essentially what happened with the magnetic field around the giant black hole at the center of galaxy M87 — except this black hole is 6.5 billion times heavier than our Sun. Scientists noticed this flip by watching the powerful beam of energy, called a jet, that shoots out from the black hole. The direction and behavior of that beam changed in a way that revealed the magnetic field had reversed. It's a big deal because those magnetic fields are thought to act like the engine that powers and steers these cosmic jets, and we've rarely caught one flipping in action.

Scientific American·

The 2026 World Cup's grass is an engineering problem

Imagine you're trying to play soccer in 16 different places across the United States, Canada, and Mexico — some in freezing cold, some blazing hot, some in stadiums with roofs that block sunlight. Half of those stadiums normally use fake grass. Now FIFA, the organization that runs the World Cup, wants every single pitch to feel and play exactly the same way, like a video game where every level has identical physics. To do that, they hired grass scientists — yes, that's a real job — who figured out how to grow special grass on thin mats with plastic underneath so it can be transported like a carpet, stitched with synthetic fibers so it doesn't rip when players sprint and tackle, and tested by literally shooting balls at it with a cannon to make sure it bounces right. Different grass species are used depending on whether a stadium is hot, cool, or dark. It's basically a giant, living, high-tech floor installation that has to survive the world's best athletes running on it.

Nature Genetics·

Non-Mendelian inheritance of DNA methylation patterns in mice

Imagine your DNA is like a huge book of instructions. Mendel's laws are the normal rules for how chapters of that book get passed from parents to children. But there's also a layer of sticky notes on top of the book—called epigenetic marks—that tell cells which chapters to read and which to ignore. This study found that most of the time (about 93%), these sticky notes follow the normal inheritance rules. But about 7% of the time, they do something unexpected: new patterns appear that neither parent had, or a mark from one parent somehow silences the same mark from the other parent (called paramutation), or males and females end up with completely different sticky notes even when they inherit the same DNA. Scientists discovered this by using a new ultra-precise DNA reading technology in mice, and it opens the door to understanding hidden layers of how traits—and possibly diseases—are passed down through generations.

New England Journal of Medicine·

Digital twin–guided ablation for ventricular tachycardia

Imagine your heart is a city, and ventricular tachycardia is like a traffic jam caused by a broken road — electrical signals get stuck going in circles instead of flowing properly, causing the heart to beat dangerously fast. Doctors can fix this by burning away the broken road using a procedure called ablation. The problem is, finding the exact broken road inside a beating heart is like navigating a city you've never visited before, while driving, in the dark. What these researchers did is take detailed MRI pictures of each patient's heart, build a 3D computer copy — a 'digital twin' — and then simulate where the electrical problem was happening inside that virtual heart. They tested their fix on the computer model first, figured out exactly where to go, and THEN performed the real procedure. What used to take three hours of exploratory surgery was done in about 30 minutes, because the doctors already had a GPS map before they started.