Building the culture — human stem cells, astrocytes, and 800,000 neurons
Transcript
This chapter, from the episode video's captions · 460 words
20:22this comes pretty close for literally 90% of applications. So, it's it's done a huge service for the biomedical industry because for 90% of applications, I don't need to worry about that. That's still a huge unlock. I just want to be very clear here. So let's talk about the culture that they made. They made 800,000 neurons co-cultured with aststerytes. This is pretty incredible here. >> Okay, >> usually when we make stem cells, right, and we make a culture of cortical tissue, >> you're going to have all neurons. >> That actually is not ideal. Okay, >> for certain applications it is like when we were discussing the ALS story and we wanted to create um an ALS mini brain on
21:05a petri dish. We wanted it to be all motor neurons, right? Because then that's how we test the drugs and so on and so forth. In this case, we want like a live computing unit >> that kind of mimics the human brain like or at least a small chunk of the human brain. And the human brain is not just neurons. The human brain has astroytes. So if we look over here, what they've been able to do is grow neurons along with aststerytes and all of the supporting cells. >> Okay? So the blue that DA um DAPI, >> yes, >> those are marking the neurons, >> the GFAP and the red those are marking supporting aststerytes and those are
21:46critical for long-term functioning. Okay. >> Okay. So this is sort of a secret sauce that allows those cultures in that petri dish to survive for a lot longer. So now they can learn over a longer time scale and you know actually now we can take neurocomputing seriously. >> If you have a professional sports team with these high high skill athletes, >> they're nothing without the training and medical staff. >> Exactly. that enable them to continue to perform over a longer periods of time given the amount of stress and and things that are going on. >> Exactly. And so these are all these supporting cells which are crucial to creating a comput like you know a little
22:27piece of computation on that petri dish. It's not just all neurons. You got to have sort of a mimicked brain environment and they were very successful at doing that. So now that's the side of the cells. We've we've created a really nice culture with 800,000 neurons. That's a lot of neurons, right? Okay. Now, let's go into the multi-elerode array. >> I'm sorry. I just want to interrupt you really briefly. Is is so the 800,000 neurons is that would that be comparable to saying like the GPUs in your Nvidia
From Can Human Neurons Really Play Doom? The Science Behind Wetware
Did a dish of human neurons really learn to play Doom—or is the wetware story more hype than breakthrough?