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1:37:40and then you ask the model, okay, now try and predict where the cancer is going to go and you follow that second sister >> cells to see how it would move >> and it's tracking. >> I'm so mad. >> Right. >> That's kind of nice. >> This is this is this is really good. This is this is really good. The the point is we created a map a 22dimensional space map >> of a fitness landscape. Mhm. >> using that library that was created in that previous nature paper and I think it was 2021. >> Yeah. >> And the idea was this was used to be this theoretical concept that's actually uh like literal. >> Yeah. >> Like it translates literally. We created our Google maps of of cancer and we took
1:38:22one cancer cell we split into two. >> We create generated the map based off of one and then the real world other one traversed what the map said it would traverse. Yep. >> Meaning that that f fitness landscape is literal. >> Yeah. >> And it's like literal. >> Yeah. Yeah. Like there is a fitness landscape and these guys are following it, right? Um in chemotherapy, this this works out really well. So um cyplatin, which is a type of chemotherapy, >> one could ask, well, you've made a fitness landscape. Now suppose I introduce a stress like cislat sysplatin. That's going to completely change the fitness landscape, right? It's going to be now dynamic because certain hills are going to become
1:39:02valleys and so on and so forth. >> Yes. >> Can you um >> can you predict there and and they could they could show that there was an increased variance and this actually um is in support of something called punctuated equilibrium which is a model of evolution that is not gradualism. In gradualism you get changes very gradually over time. Punctuated equilibrium is there's a stress that stress leads to bifurcations in your