Topic

Transcriptomics

Episodes and research papers from From First Principles that help explain Transcriptomics from the ground up.

Research

Papers and studies featured by the show.

PNAS Nexus·

Extremophile survives the transient pressures associated with impact-induced ejection from Mars

Imagine a massive asteroid hitting Mars so hard that it blasts chunks of rock into space - some of these rocks eventually land on Earth as meteorites. Scientists wanted to know: if there were tiny life forms (bacteria) living in those Martian rocks, could they survive the incredible shock of being launched into space? They took one of Earth's toughest bacteria, Deinococcus radiodurans (nicknamed "Conan the Bacterium"), and subjected it to the same crushing pressures that would occur during such an impact. Amazingly, most of the bacteria survived pressures that would instantly crush almost any other living thing. This suggests that life could potentially hitchhike between planets on rocks, surviving the violent journey through space.

Nature·

A ‘time capsule’ for cells stores the secret experiences of their past

Imagine your cells have millions of tiny, hollow barrels inside them called vaults, and for decades, nobody knew what they were for. Scientists in this study figured out how to open these barrels and put a specific, rolled-up instruction sheet (that's the mRNA) inside. They also designed a special key that can unlock the barrel and release the instructions at a later time. So, they've essentially created a microscopic time capsule inside a living cell, allowing them to tell a cell what to do and, crucially, *when* to do it.