Topic
Biochemistry
Episodes and research papers from From First Principles that help explain Biochemistry from the ground up.
Research
Papers and studies featured by the show.
A ‘time capsule’ for cells stores the secret experiences of their past
Imagine your cells have millions of tiny, hollow barrels inside them called vaults, and for decades, nobody knew what they were for. Scientists in this study figured out how to open these barrels and put a specific, rolled-up instruction sheet (that's the mRNA) inside. They also designed a special key that can unlock the barrel and release the instructions at a later time. So, they've essentially created a microscopic time capsule inside a living cell, allowing them to tell a cell what to do and, crucially, *when* to do it.
Civet Robusta and natural Robusta coffee are different on key fatty acid methyl esters and total fat
Imagine a coffee bean going through a special flavor factory, which is the civet's stomach. As the bean passes through, the animal's digestive juices act on it, kind of like a marinade. This process adds more of specific types of fats to the bean. These particular fats are known to create creamy, smooth flavors and smells, similar to dairy. So, the scientists found that the civet isn't just picking the best beans; its body is actively changing their chemistry to make them less bitter and more flavorful.