Biomedical Engineering
The #HOPE4LIVER Single-Arm Pivotal Trial for Histotripsy of Primary and Metastatic Liver Tumors
In plain English
The prospective HOPE4LIVER trials evaluated histotripsy for primary and metastatic liver tumors. The study met its technical-success and safety endpoints; those endpoints should be distinguished from proof of long-term cancer control or cure.
On the show2
- EP 59
Golden Goose Awards 2026: The Science Behind the Winners (Part 1)
Explore the science behind the 2026 Golden Goose Awards, from ultrasound that destroys tumors to NASA’s night lights and the deep physics of everyday life.

- EP 66
Destroying Tumors With Sound: Histotripsy with Dr. Zhen Xu
Dr. Zhen Xu explains how an unexpected ultrasound result became histotripsy, from bubble physics to liver-tumor treatment and the questions still ahead.
