GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition
TL;DR
This study shows that certain genes in golden retrievers are linked to behavioral traits like aggression and trainability, which also correspond to similar traits in humans, including intelligence and mental health issues. Understanding these genetic connections can help improve dog behavior and our approach to mental health in both dogs and humans.
Dogs display temperamental and behavioral variation between individuals, just as psychiatric, temperamental, and cognitive traits vary in humans. In both species, these traits are highly heritable, yet causal genes remain incompletely understood. We performed 14 genome-wide association studies (GWAS) for behavioral traits quantified using the Canine Behavioral Assessment and Research Questionnaire (C-BARQ) in ~1,000 golden retrievers, identifying 12 genome-wide significant loci (P -6) for 8 traits and 9 additional loci exceeding a suggestive threshold (P -5). A human phenome-wide association study (PheWAS) showed that most of the 18 canine positional candidate genes identified were associated with one or more of 190 psychiatric, temperamental, or cognitive traits in humans (7/12 genes at genome-wide loci and 5/9 at suggestive loci). For example, a genome-wide significant locus near PTPN1 (dog-directed aggression) overlapped with human measures of Intelligence, Educational attainment, and major depressive disorder. The gene ROMO1 was within a genome-wide significant locus for trainability in dogs and associated with intelligence, depression, irritability, and sensitivity/hurt feelings in humans. Other genes located at genome-wide significant loci associated with behavioral, psychiatric, temperamental, or cognitive traits in both species included PRDX1(dog-directed fear), VWA8 (touch sensitivity), ITPR2, and ADGRL2/LPHN2 (trainability), and ADD2 (stranger-directed fear). From suggestive loci we also found cross-species associations for HUNK, and ZC3H12C, (dog-directed fear), SLC35F6 and IGSF11 (separation-related problems). These results suggest that shared genetic and molecular mechanisms underlie complex behavioral and temperamental states across species and may inform our understanding of emotional states driving undesirable behaviors in dogs.
- 1Identified 12 specific gene regions linked to 8 behavioral traits in golden retrievers.
- 2Most of these genetic regions in dogs are also associated with psychiatric and cognitive traits in humans.
- 3Genes like PTPN1 are related to aggression in dogs and human intelligence, while ROMO1 links trainability in dogs to human emotional traits.
- 4Suggestive genetic links also exist for separation anxiety in dogs and its behavioral parallels in people.
The 2026 World Cup's grass is an engineering problem
Imagine you're trying to play soccer in 16 different places across the United States, Canada, and Mexico — some in freezing cold, some blazing hot, some in stadiums with roofs that block sunlight. Half of those stadiums normally use fake grass. Now FIFA, the organization that runs the World Cup, wants every single pitch to feel and play exactly the same way, like a video game where every level has identical physics. To do that, they hired grass scientists — yes, that's a real job — who figured out how to grow special grass on thin mats with plastic underneath so it can be transported like a carpet, stitched with synthetic fibers so it doesn't rip when players sprint and tackle, and tested by literally shooting balls at it with a cannon to make sure it bounces right. Different grass species are used depending on whether a stadium is hot, cool, or dark. It's basically a giant, living, high-tech floor installation that has to survive the world's best athletes running on it.
Non-Mendelian inheritance of DNA methylation patterns in mice
Imagine your DNA is like a huge book of instructions. Mendel's laws are the normal rules for how chapters of that book get passed from parents to children. But there's also a layer of sticky notes on top of the book—called epigenetic marks—that tell cells which chapters to read and which to ignore. This study found that most of the time (about 93%), these sticky notes follow the normal inheritance rules. But about 7% of the time, they do something unexpected: new patterns appear that neither parent had, or a mark from one parent somehow silences the same mark from the other parent (called paramutation), or males and females end up with completely different sticky notes even when they inherit the same DNA. Scientists discovered this by using a new ultra-precise DNA reading technology in mice, and it opens the door to understanding hidden layers of how traits—and possibly diseases—are passed down through generations.
Adversarial AI reveals mechanisms and treatments for disorders of consciousness
Imagine your brain is like a city with millions of roads and traffic systems. When you're awake and conscious, traffic flows in complex, coordinated patterns. In a coma, something has gone wrong — but we've never had a great way to figure out exactly which roads are broken or how to fix them. This study built a very smart AI that learned to tell the difference between 'awake brain' and 'coma brain' by studying hundreds of thousands of brainwave recordings. Then, like a detective, the AI was pitted against a simulated model of the brain to figure out: what changes in the brain's wiring would explain the difference? The AI figured out — on its own, without being told — that two key things go wrong in a coma: a specific circuit deep in the brain (called the basal ganglia indirect pathway) gets disrupted, and the brain's 'braking system' (inhibitory neurons) starts working too hard in the wrong places. The researchers then checked these predictions against real patient data, and both checked out. The AI also suggested that zapping a specific deep brain region with high-frequency electrical pulses might help wake people up — and early evidence from human patients supports this idea.
Trionda: Enhanced Surface Roughness Relative to Previous FIFA World Cup Match Balls
Imagine throwing a ball through air. The air pushes back on the ball, slowing it down—that's called drag. But something interesting happens: at a certain speed, the air flowing around the ball switches from a smooth, lazy flow to a chaotic, turbulent flow, and paradoxically the ball actually experiences LESS drag in that turbulent zone. Think of it like a golf ball—those dimples are there precisely to trigger this turbulence early and make the ball fly farther. The speed at which this switch happens is called the 'critical speed' or 'drag crisis.' Scientists put the Trionda ball in a wind tunnel—basically a giant fan tube—and measured exactly how much air resistance it faces at different speeds. They found that Trionda's surface is effectively rougher than most previous World Cup balls, meaning it hits that drag crisis switch at a lower speed (11.9 meters per second, roughly 27 mph). In plain terms, Trionda behaves more predictably in flight than some past balls, but very long, powerful kicks may travel slightly shorter distances than they would have with previous balls.