From Cells to Circuits to Crystals — 2025 Nobel Prizes Unpacked

Hosted by Lester Nare and Krishna Choudhary, this From First Principles special brings all three 2025 Nobel Prizes in the sciences into one 2 hour episode. From the immune system’s “peacekeepers” that prevent autoimmunity, to superconducting circuits behaving as single quantum objects, to modular materials that build “new rooms for chemistry,” this is your complete Nobel Week in one place.

Summary

• Day 1 | Medicine: Peripheral immune tolerance (Brunkow, Ramsdell, Sakaguchi)

• Day 2 | Physics: Macroscopic quantum tunneling and energy quantization (Clarke, Devoret, Martinis)

• Day 3 | Chemistry: Metal–Organic Frameworks (MOFs) (Kitagawa, Robson, Yaghi)